A Comparative Study of Alcohol Percentage in Homeopathic Mother Tinctures by using GCHS & Conventional Method in Respect to Accuracy and Efficiency
(Advancements in Homeopathic Research, Vol. 9 No.3, August 2024-October 2024, Date of Publication 2024/08/01, Pages no. 4-9 ISSN : 2456-3668 (Print) // EISSN : 2583-5661 (Online) DOI : 10.48165/ ahr.2024.9.3.1)
Dr. Arun Kumar1, Dr. Narendra Kumar Gaur1, Dr. Sunil Kumar Vishwakarma1, Dr. Snigdha Suman Dalua2, Dr. Poorva Tiwari2, Dr. Ramachandran Valavan2
1Quality Control Department, Dr.Willmar Schwabe India Pvt. Ltd., A36, Sector 60, Noida, India. Pin– 201304.
2Scientific and Medical Affairs Department,
Dr. Willmar Schwabe India Pvt. Ltd., A 36, Sector 60, Noida, India. Pin – 201304.
Corresponding author:
Dr. R. Valavan,
BHMS, MD (Hom), MBA, PhD, Head – Scientific, Medical & Regulatory Affairs, Dr. Willmar Schwabe India Pvt. Ltd.,
A 36, Sector 60, Noida, India. Pin – 201 304.
Mobile:+91-93123 09186.
Email: dr.valavan@schwabeindia.com,
drvalavan@yahoo.com.
Abstract
Introduction: Technological advancement in homeopathic quality control helps for more accuracy in data & consumes less time. Technology progression has led to inclusion of modern instruments like UV spectroscopy, HPTLC, gas chromatography in homeopathic quality control. Assessment of alcohol percentage in homeopathic mother tincture is an essential quality parameter. However, estimation of alcohol percentage by using conventional method (CM) as described in Homeopathic Pharmacopoeia of India is time consuming at commercial level. Advanced technology of gas chromatography with head space (GCHS) is considered to minimise the process time, improve the efficiency, and provide more accuracy. However, there is no study to validate this statement in homeopathic industry. This study is aimed to find out the difference in both the methods.
Method: Ten mother tinctures were chosen, and their alcohol content was determined intriplicate by using CM with the help of pycnometer and by using GCHS.
Result and discussion: 10 mother tinctures i.e. Ammi visnaga, Aspidosperma, Azadirachta indica, Chelidonium majus, Cydonia vulgaris, Equisetum hyemale, Gelsemium sempervirens, Ginseng, Holarrhena antidysenterica and Syzygium jambolanum have been studied. Mean alcohol content with standard deviation in CM are 59.5 (SD-0.205), 94.4 (SD- 0.235), 59.69 (SD-0.369), 43.25 (SD-0.053), 31.66 (SD-0.364), 58.54 (SD-0.596), 58.72 (SD-0.296), 57.34 (SD-0.525) and 84.83 (SD-0.377) and in GCHS are 59.26 (SD-0.068), 93.88 (SD-0.07), 59.36 (SD- 0.178), 44.16 (SD- 0.034), 32.04 (SD- 0.294), 58.38 (SD0.392), 59.44(SD- 0.179), 94.01 (SD-0.075), 56.61 (SD-0.495) and 83.59 (SD-0.21) respectively. It is observed that distribution, standard deviation and coefficient of variance of all samples are much lower in GCHS method than CM. It signifies that the results are more accurate in GCHS. CM took more time than GCHS. 8 samples could be performed by using CM vs 25 samples in GCHS. However, CM is cost-effective.
Conclusion: GCHS is found to be more accurate and less time consuming to determine the alcohol content of homeopathic mother tinctures, though it is costlier.
Keywords: GCHS, homeopathic mother tincture, alcohol percentage in mother tincture.
ISSN – 2456-3668 (P) * EISSN – 2583-5661 (O) * Vol. 9 No.3, August 2024-October 2024 (pp. 4-9) DOI : 10.48165/ahr. 2024.9.3.1